That the phagocytes play an important rôle in combating certain infections in man, and certain experimental infections in laboratory animals, can hardly be doubted by those who are familiar with the researches of Metchnikoff and his followers. It can be demonstrated that the leucocytes, both in the animal body and in testtube experiments, take up many cocci and bacilli and apparently destroy them. It has, however, long been a disputed question whether the body fluids take part in this phagocytosis, and, if so, in what way. Some experimenters have believed that these fluids play no part, because they found, for instance, that there may be phagocytosis of the pyogenic cocci, although these organisms multiply rapidly in the cell-free serum and blood plasma of the animals which furnish the phagocytes. On the other hand, there were those who went to the other extreme and held that the phagocytes take up the
THE ROLE OF THE BODY FLUIDS IN PHAGOCYTOSIS.. JAMA. 1904;XLII(26):1689. doi:10.1001/jama.1904.02490710021005
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