Unfortunately, we are not much farther advanced in the chemistry of the thyroid gland than we were two years ago when I wrote the section on organotherapy for Cohen's "System of Physiologic Therapeutics." In other words, we can not give any one portion of this gland activity to a patient without giving the whole of it. We know that the active principles are absorbed from the gastrointestinal canal, but whether any particular activity is lost in this chemistry we do not know.
The physiologic symptoms developed by feeding thyroid are well known, viz., thyroid extract will increase the rapidity of the heart; increase perspiration; cause warming of the surface of the body, in other words increase the peripheral circulation; lower the blood pressure; stimulate mental activity even to sleeplessness; cause increased nitrogenous metabolism, and if in considerable amount or given for a time, cause loss of weight. The physiologic actions
OSBORNE OT. THE THERAPEUTIC USES OF THYROID PREPARATIONS. JAMA. 1906;XLVII(18):1475–1479. doi:10.1001/jama.1906.25210180051001m
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