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Article
November 3, 1906

DIPHTHERIA ANTITOXIN IN THE TREATMENT OF EXOPHTHALMIC GOITER.

JAMA. 1906;XLVII(18):1486. doi:10.1001/jama.1906.25210180062002e
Abstract

The symposium on "Exophthalmic Goiter"1 reminds me of a short report2 under the same heading as my note, written by Dr. Robert T. Legge, of McCloud, Cal. The doctor reported several cases of the above disease, in which he had used diphtheria antitoxin with curative results.

Prompted by his report, I lately used the same antitoxin for the same disease, and also with very satisfactory results. For, though only about five weeks have elapsed since the injection (of 3,000 units), already the tumor has almost disappeared, the circumference of the neck having diminished almost one and one-half inches. The pulse rate has fallen from 135 to 80; the tremor, before injection very marked, is now almost imperceptible; the exophthalmos can no longer be detected; the nervousness and weakness have almost disappeared. There have been no untoward effects whatever. No other treatment has been used except local inunction with

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