Nephritis is an unfortunately common and fatal complication of scarlet fever, and the careful clinician is always on the lookout for its development, meanwhile employing such measures as are best calculated to abort its occurrence. To this end he strives to keep the temperature within reasonable limits, and he lessens the demands on the kidneys. insofar as he can, by increasing the activity of the other emunctories, namely, the skin, the intestinal tract and the lungs, while at the same time he flushes the kidneys by means of water introduced into the system by way of the stomach or the rectum or the subcutaneous tissues or even of the veins. It has been suggested that a useful purpose might be subserved in the prophylaxis of nephritis complicating scarlet fever by the administration of hexamethylene tetramin, also known commercially as formin, urotropin, cystogen, aminoform, etc., and reports have been made of
THE PREVENTION OF NEPHRITIS AS A COMPLICATION OF SCARLET FEVER.. JAMA. 1904;XLIII(2):128. doi:10.1001/jama.1904.02500020042012
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