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July 18, 1896


JAMA. 1896;XXVII(3):134-138. doi:10.1001/jama.1896.02430810018001f

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Among the many principles on which are based our modern theories of the etiology and therapeutics of disease is that of the vaccinating or immunizing power of attenuated cultures of specific microörganisms. Although this principle is forecast by Jenner's discovery of the vaccine against variola, it is to the great Frenchman, Pasteur, that should be ascribed its first scientific development.

In 1880 this investigator showed that an attenuated culture of the microbe of chicken cholera, injected into animals, would produce a mild attack of the septicemia, and would leave them immune against a second attack. This was the first experimental fact to which numerous laboratory workers have been adding during the last fifteen years. Disease after disease has been added to the list, anthrax, hog cholera, malignant edema, hydrophobia, diphtheria, the infections due to the staphylococcus, the streptococcus and the pneumococcus, typhoid fever and tetanus.

It is not the purpose

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