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November 17, 1906


JAMA. 1906;XLVII(20):1621-1623. doi:10.1001/jama.1906.25210200017001c

Albuminuria is nothing but a symptom of disease. The cause of the symptom may be anterenal, renal or postrenal, and may be due to structural change or to pathologic function. Postrenal albuminuria, an admixture of various adventitious proteid substances with the urine after this has left the renal tubules, does not come within the scope of the subject under consideration. In the case of anterenal or renal causes, it is the albumin of the serum, or rather albumin having passed through the circulation which has found its way into the urine. We are perfectly justified in accepting anterenal factors of albuminuria when we are confronted with a large albumin output without corresponding kidney lesion as shown by the presence of goodly amounts of tubular epithelium. We may yet go a step further and maintain that native serum albumin occurring in normal amounts can not be eliminated, even by a structurally

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