A diabetic patient with a low acidosis and with no trace of albumin in the urine, when put on a meat fat diet, showed a constant ratio of dextrose to nitrogen in the urine. The ratio was Dextrose: Nitrogen=3.65:1, and is the same as that found in dogs made diabetic with phlorhizin. This ratio was uninfluenced by fat digestion or by fat metabolism. The sugar was, therefore, derived from proteid alone, and rose and fell with the proteid metabolism as indicated by the amount of urinary nitrogen. The patient died five weeks later.
There was apparently a complete intolerance for carbohydrates.; 85 per cent. of starch and 80 per cent. of levulose fed were excreted as sugar in the urine. Withdrawal of the carbohydrates from the diet and the continuance of the same proteid-fat quantity in the food had no effect on the excretion of nitrogen in
ARTHUR R. MANDEL, GRAHAM LUSK. DIABETES MELLITUS.REPORT ON A CASE, INCLUDING A NEW METHOD OF PROGNOSIS.. JAMA. 1904;XLIII(4):241–242. doi:10.1001/jama.1904.92500040002b