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July 30, 1904


JAMA. 1904;XLIII(5):318-321. doi:10.1001/jama.1904.92500050001g

Most of the observations recorded in this paper are not new. The literature on vaccine contains such a diversity of statements, in regard to its reactions and limitations, that one is often at a loss to know just what to believe in regard to a given statement.

EXPERIMENTS.  The following experiments were undertaken in order to satisfy myself in regard to the various reactions mentioned:

EXPERIMENTS ON CALVES.  A heifer about three months old was fed per os six ounces of an emulsion of active vaccine. Ten days later there were observed a few large, typical, umbilicated vesicles on the legs in the region of the groin and around the udder.A heifer was injected intravenously with 5 c.c. of an emulsion of active vaccine. Nine days later a large number of well-developed vesicles were discovered in the region of the injection, on the opposite side of the

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