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August 6, 1904


JAMA. 1904;XLIII(6):381-383. doi:10.1001/jama.1904.92500060001e

Until the more recent work of Martini and Lentz, the bacillus discovered by Shiga as the cause of Japanese dysentery, the bacillus isolated later by Flexner and Strong in the Philippines, Kruse in Germany and Vedder and myself in this country were thought to be culturally identical, except for the minor inconstant differences as shown in the ordinary media then employed, which differences might be expected of individuals of the same species. Martini and Lentz, employing a mannite medium, discovered that certain of these isolations would ferment and others fail to ferment with acid production on this alcohol. Still more recent studies by workers in this country have determined other cultural differences between various isolations in their action on certain special sugars.

These cultural distinctions between the bacilli are in conformity with variations in agglutination reaction; based on these important differences, we now speak of members or strains of the

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