During the past decade a suspicion has developed that various intracranial growths produce disturbances of menstruation, especially in the direction of scantiness or even complete absence. In 1903 Axenfeld1 pointed out that tumors of the base of the brain, especially those which involve the hypophysis cerebri, are most commonly productive of cessation of menstruation. For some years it had been recognized that acromegaly, especially in young persons, was likely to have complete amenorrhea as one of its first symptoms. Cessation of menstruation often declared itself many months before any other symptom of acromegaly could be observed and usually was treated in many ways before the hopelessness of the condition was realized with the inevitable advance of the nervous and tissue manifestations. In these cases a relationship between optic atrophy and the disturbance of menstruation was an early symptom and optic atrophy was also likely to develop early. The two
AMENORRHEA AND BRAIN TUMOR. JAMA. 1906;XLVII(26):2162. doi:10.1001/jama.1906.02520260032003
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