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The salicylates have been so widely employed and have proved of such distinct utility in the treatment of a large number of disorders, that the fact should not be ignored that they may give rise to irritation of the urinary tract, particularly the kidneys. Some observers have even reported the occurrence of nephritis and desquamative catarrh of the urinary passages from this cause. In order to convince themselves of the accuracy or otherwise of statements of this character, Dr. Carl Klieneberger and Dr. Richard Oxenius1 made a careful study of the urine from a large number of practically normal persons and from individuals suffering from rheumatic disorders, particularly polyarthritis, to whom later salicylates were administered. As a result of their observations they found that the administration of even small doses of salicylates gave rise to the urinary, but not to other clinical phenomena of nephritis and also of desquamative
THE ACTION OF SALICYLATES ON THE URINARY TRACT. JAMA. 1904;XLIII(8):552. doi:10.1001/jama.1904.02500080030007
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