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August 27, 1904


JAMA. 1904;XLIII(9):581-586. doi:10.1001/jama.1904.92500090001

The chief object of this paper is to demonstrate that inefficient tone of unstriated muscular fiber is a common and serious element of disease; and that it is important to guard against, or to correct, such abnormal state of that tissue.

The secondary object is to show that a drug which has been used therapeutically for three centuries for a single purpose, and for three decades for but one additional purpose, is the best medicinal agent at our command with which to tone the weak, relaxed, or paralyzed unstriped fiber, and, therefore, deserves, without exception, the first place, the place of honor and trust, in the physician's emergency case.

The most common manifestation of atony of the unstriped fiber is an abnormal disturbance of the equable distribution of blood throughout the body. The relation of the blood supply to the several organs or regions

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