The discovery of the remarkable property of the animal body to produce antitoxins in response to the injection of toxins has opened up an entirely new field of investigation in physiology. Very extensive experiments have been carried out by a large number of investigators in the hope of discovering the mechanism and the exact location of the production of these antibodies. but very little is as yet definitely known. Several theories have also been advanced to explain this process, but none of them is entirely satisfactory. It has been shown, for instance, that antiabrin and cholera immune bodies are present in the spleen and in the bone marrow of an animal, in the process of immunization, before they can be found in any other part of the body. It has also been shown that an emulsion of brain tissue has antitetanic properties, and substances having antitetanic properties have been isolated
THE PRODUCTION OF ANTITOXIN BY AUTOLYSIS. JAMA. 1904;XLIII(9):610–611. doi:10.1001/jama.1904.02500090030005
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