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Article
September 3, 1904

REGENERATIVE CHANGES IN CIRRHOSIS OF THE LIVER.

Author Affiliations

Associate Professor of Pathology in Johns Hopkins University. BALTIMORE.

JAMA. 1904;XLIII(10):649-654. doi:10.1001/jama.1904.92500100001b
Abstract

In the literature and in the text-books of pathology little reference is made to the evidences of regeneration in cirrhosis of the liver. It is true that it is stated that regenerative changes are evident in certain cases leading to the production of adenoma-like nodular masses of liver tissue, and there is in general a tendency to regard the bile duct-like structures which occur in the fibrous bands as newly formed and as representing an effort toward the restitution of the liver to its original bulk. Especial stress is, however, usually laid on the degenerative changes in the liver cells and the anatomic picture presented by a cirrhotic liver is commonly looked on as the expression of a steadily progressive destructive process.

Kretz1 only, so far as I can see in the literature at my command, has especially emphasized the importance of the regenerative changes in the ordinary

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