The first recorded utilization of the x-ray for the treatment of leukemia was by Pusey,1 who observed no effect whatever in a case of the splenomyelogenic type, but in one of the lymphatic type he noticed a marked diminution in the size of the glands. More recently a fresh interest in the subject has been aroused by the favorable reports of Senn,2 Brown3 and others.4
In all we have seen reports of 11 cases of well-verified leukemia treated in this way. All but one of these belonged to the splenomyelogenic type. In every instance the splenic tumor decreased in size, in 3 cases becoming barely palpable. The leucocytes in all cases excepting Pusey's diminished in number. Four reporters record a white count under 10,000, with entire disappearance of the myelocytes. An improvement in the hemoglobin and red corpuscles always took place, but was
CAPPS JA, SMITH JF. X-RAY THERAPY IN LEUKEMIA.A PRELIMINARY REPORT. WITH SPECIAL REFERENCE TO LYMPHATIC LEUKEMIA. JAMA. 1904;XLIII(13):891. doi:10.1001/jama.1904.92500130001h
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