Among the still obscure physiologic problems must be reckoned those relating to the mechanism regulating growth and decay. While we are in possession of isolated scraps of knowledge which shed an occasional glimmer of light on the subject, our knowledge can only be described as fragmentary. The studies of the last few years on acromegaly and giantism indicate that the pituitary body has some influence on development, though just what this influence is remains obscure. In some cases of dwarfism, too, this gland has been found diseased. In some forms of dwarfism again the thyroid seems to play a part, as is the case in cretinism and allied conditions. Then, again,certain glands seem to bear a relation to certain systems rather than to the body as a whole, an example of this being the curious relation which exists between excessive or premature development of the genitalia and some of the
PROGERIA, A FORM OF SENILISM. JAMA. 1904;XLIII(13):894–895. doi:10.1001/jama.1904.02500130042005
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