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Article
October 1, 1904

OSMIC ACID INJECTIONS FOR RELIEF OF TRIFACIAL NEURALGIA.

JAMA. 1904;XLIII(14):947-955. doi:10.1001/jama.1904.92500140001f
Abstract

The publication of Delbastaille's1 article on the injection of osmic acid in inoperable tumors and its subsequent use in the same direction by von Winiwarter2 and others, attracted much attention, but the results were unfavorable and its use was abandoned. During this experimentation Neuber reasoned that, as osmic acid has a special affinity for the medulla of peripheral nerves as a stain, it might prove beneficial in a clinical way. At this juncture a patient presented himself who had been suffering from neuralgia of the first and second branches for six years on whom, Aug. 15, 1880, a resection of the second division by Professor Albert, on the plan of Lücke, von Bruns and Lassen, had been made. The patient experienced relief for one year, then had several relapses. On Nov. 30, 1882, there was a ligation of the carotid, with no relief. From Jan. 18 to Feb. 9, 1883

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