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October 1, 1904

THE ETIOLOGY OF HAY FEVER.THE RELATION OF THE CHEMISTRY OF THE SALIVA AND THE NASAL SECRETIONS TO DISEASES OF THE MUCOUS MEMBRANE OF THE MOUTH AND UPPER RESPIRATORY TRACT.

JAMA. 1904;XLIII(14):966-972. doi:10.1001/jama.1904.92500140001i
Abstract

While this paper has special reference to the etiology of hay fever, it is necessary to go into the chemistry and pathology of the saliva and nasal secretions before taking up the special subject.In doing this, I take the liberty of quoting from my pievious papers on the subject.

In the chemic study of the nasal and salivary secretions we may conveniently classify them under three varieties: First, secretions, non-irritating per se, which on exposure (when coming to the surface) undergo some chemic change producing an irritant; this may be noted in either an acid or alkaline secretion. As I will show later, an exceedingly alkaline secretion is decidedly more irritating and productive of a more destructive pathologic process than even a strongly acid secretion Second, secretions which are irritating per se when poured out on the surface. Third, secretions which come to the surface in a non-irritating form,

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