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Article
October 8, 1904

THE PATHOGENESIS OF UREMIA AND ECLAMPSIA.

Author Affiliations

PHILADELPHIA.

JAMA. 1904;XLIII(15):1019-1022. doi:10.1001/jama.1904.92500150001
Abstract

Under a rather hackneyed title, it is my purpose to discuss very briefly a subject that will always be of interest until the mystery which surrounds the direct causal influences of uremia and eclampsia is entirely and finally dispelled.

None of the theories offered up to the present time has been thoroughly satisfactory in explaining either the uremic state, which seems to be associated always with renal insufficiency, or that of eclampsia, which may or may not be preceded by signs of renal disability, but presents an almost identical clinical picture. I think it fair to state that I have never seen a case of eclampsia in which the urine, drawn by catheter during the coma or the convulsive period, failed to give abundant evidence of a serious renal involvement. I have seen this statement borne out in cases in which there was neither a trace of albumin nor a single form of renal sediment distinguishable by the microscope prior to the onset of the convulsive seizure.

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