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Leukemia is usually a disease of insidious onset and slowly progressive course. Occasionally, however, it makes its appearance with the abruptness of an acute infection, being attended with febrile symptoms and other manifestations of constitutional disturbance. Of the etiologic influences we know little, if anything. The disease has been observed in connection with malaria, syphilis, other infectious diseases, traumatism, over-exertion and profuse hemorrhage. It has developed during pregnancy, and sometimes an hereditary predisposition has existed. The disease has also been observed in some of the lower animals. Males seem to suffer more commonly than females. No age appears to be exempt, though it is probable that the disease is most common during the middle period of life.
To the rather small list of cases of acute leukemia in childhood Theodor (Archiv für Kinderheilkunde, B. xxii, H. 1, 2, p. 47) adds the report of an additional instance, together with an
ACUTE LEUKEMIA IN CHILDHOOD. JAMA. 1897;XXVIII(20):950. doi:https://doi.org/10.1001/jama.1897.02440200040009
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