According to generally accepted statistics, one adult in every ten is the subject of gallstone. Of these about 5 per cent. suffer from symptoms of the disease. A proportion of these cases show such marked symptoms that the diagnosis is easily made, and the condition is readily recognized. A larger proportion of cases, however, present such vague symptoms, or symptoms so little understood by the general practitioner, that diagnosis is not made, and many patients who are much in need of relief which surgery might give, continue as chronic invalids for years until some severe crisis brings them to an untimely end. Owing to the efforts of many able scientists, prominent among whom are Mayo Robson, Kehr, Brewer, the Mayos, Murphy and Richardson, much has been done toward throwing the searchlight of knowledge into that region which has been called the mysterious realm of surgical romance, namely, the right
SYMS P. DIAGNOSIS OF CHOLECYSTITIS AND CHOLELITHIASIS.. JAMA. 1904;XLIII(16):1109–1111. doi:10.1001/jama.1904.92500160001c
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