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April 6, 1907


JAMA. 1907;XLVIII(14):1177-1179. doi:10.1001/jama.1907.25220400029001i

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Strophanthus has not rivaled digitalis in the extent of its use, except, perhaps, for a short time after the former was brought into prominence by Fraser. This is somewhat remarkable in view of the fact that numerous investigators have found that the action of strophanthus presents certain advantages over that of digitalis; thus, strophanthus, and to a greater extent its active principle, strophanthin, act much more promptly than digitalis or digitoxin. Fraenkel found that the action of a single effective dose of digitoxin was delayed for many hours beyond that of a corresponding dose of strophanthin, and while he was unable to induce slowing of the cat's heart from a single non-toxic dose of digitoxin, a single non-toxic dose of strophanthin promptly proved effective. Strophanthus produces much less vasoconstriction in the splanchnic area than digitoxin does, and while this is a disadvantage in shock, it is often desirable in producing

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