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April 27, 1907


JAMA. 1907;XLVIII(17):1414-1418. doi:10.1001/jama.1907.25220430026001f

The pernicious vomiting of pregnancy, acute yellow atrophy of the liver, and eclampsia, are generally grouped together as manifestations of the toxemia of pregnancy. While eclampsia is admittedly a toxemia, it seems unwise to class it with the other two conditions, from which it differs widely in symptoms, pathology, and prognosis, if not in other respects. For this reason it seems to me that eclampsia should be studied entirely apart from the other two types. I wish it to be understood, therefore, that wherever the term toxemia is used in the present article it refers only to the toxemia responsible for pernicious vomiting and acute yellow atrophy and not to eclampsia unless so stated.

The most pronounced lesion to be found postmortem in a case of toxemia of pregnancy is a degeneration and necrosis of the parenchyma of the liver. While this lesion is characteristic of the toxemia of pregnancy,

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