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May 29, 1897

Are Coal-tar Derivatives Incompatible with Mercury?

JAMA. 1897;XXVIII(22):1042-1043. doi:10.1001/jama.1897.02440220038015

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Hot Springs, Ark., May 15, 1897.

To the Editor:  —I am interested in the above query. Some years ago, soon after the introduction of the coal tar derivatives as antipyretics, I yielded on several occasions to the inclination to prescribe what would seem a reasonable dose of calomel, soda and acetanilid, and in every instance noticed on the part of the patient an alarming distress. The toxic symptoms in each case being a marked griping of the bowels and an elevation of temperature followed by an alarming asthenic condition. I gave up the idea of combining calomel and acetanilid, until recently I was again tempted to use it in the case of a child 3 years old suffering with a gastro-intestinal disorder. Convulsions returned more severe with intense pain in bowels, increased tympanites and tenderness, the child dying from exhaustion. I do not think the dose killed the child,

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