That the secretion of the thyroid gland plays an important part in the maintenance of the metabolic equilibrium of the body would seem demonstrated by the effects resulting, on the one hand, from its production in excess, as, for example, in cases of exophthalmic goiter, and, on the other hand, from its deficiency, as in cases of myxedema and cretinism. The deficiency in secretion can be, in some measure at least, compensated for by the employment, in one form or other, of the gland or of preparations made from it. This has been done, and with no small degree of success, in cases of myxedema and cretinism especially. The only means at present known of combating an excess of the secretion consists in surgical removal of a portion of the gland, although some of the effects on the circulation can be counteracted by the employment of such agents as adrenal
THE SERUM-TREATMENT OF EXOPHTHALMIC GOITER.. JAMA. 1904;XLIII(19):1399–1400. doi:10.1001/jama.1904.02500190051007
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