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The disease diabetes mellitus has long furnished the science of medicine with some of its most difficult and obscure problems, one of the most interesting of which is that symptom-complex called diabetic coma, which in many instances brings this affection to a fatal termination. It was at first believed that this condition was induced by an effusion of serum into the arachnoid but later investigations failed to confirm this theory. The idea was then advanced that the phenomena of diabetic coma were due to the action of some toxic body on the organism and a large number of substances have from time to time been considered as the essential factors in the production of this condition. Urea was long believed to play an important part in this as in other affections characterized by marked nervous and cerebral symptoms. Repeated experiments have shown, however, that if free diuresis is maintained, as
MUNSON EL. DIABETIC COMA AND THE TREATMENT OF DIABETES MELLITUS. JAMA. 1897;XXVIII(23):1072–1074. doi:10.1001/jama.1897.02440230024002a
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