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The partial success of Professor Coley's treatment of sarcoma by the injection of the toxins of erysipelas and of the bacillus prodigiosus has aroused interest, and induced surgeons both sides of the ocean to experiment with other articles.
One of these is the extract of chelidonium majus. This is the ancient semi-domestic remedy called celandine. It is an acrid irritant having such energy that applied to the skin it causes inflammation and blisters, and applied to warts is said to destroy them by acting like a caustic.
Dr. Denicenco of Russia (Wratsch, St. Petersburg) experimented with it first in epithelioma of the lip, and having produced cures (by sloughing) he was led to use it in inoperable cancers of various parts of the body. He gives it internally by the mouth, applies it on the surface, and injects it into the tumor itself. Probably the whole effect comes from the
ANDREWS E. THE LATEST METHODS OF TREATING CARCINOMA BY HYPODERMIC INJECTION. JAMA. 1897;XXVIII(25):1159–1160. doi:10.1001/jama.1897.02440250001001
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