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December 10, 1904


JAMA. 1904;XLIII(24):1777-1781. doi:10.1001/jama.1904.92500240002j

The most rational treatment of pneumonia is that which aims to neutralize the pneumotoxins in the circulation. By the side of this object of treatment, efforts to influence the local inflammatory process are subordinate in point of practical importance. It is now universally recognized that the continuous high death rate in this disease is dependent on the toxemia, and that the cardiac exhaustion is to a greater extent due to the same cause than mechanical embarrassment. Recognizing the fact that the principal danger arises from the general pneumococcic infection, the great desirability of finding successful means of combating this source of danger must be obvious.

The effect of antipneumococcal sera, according to the reports of those who have had experience of their use, seems to manifest considerable variety both as to character and extent. A somewhat extended series of observations by a large number of careful clinical observers are now

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