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Although it is one of the most common of morbid motor symptoms and a very general accompaniment of states of weakness the phenomenon of tremor has not yet received a perfectly adequate or satisfactory explanation. We can conjecture of course its mechanism and assume, with Dana, that it is a derangement in the rhythm and force of the tonic influences proceeding from the brain to the muscles, or that it is in some way connected with impaired nervous conduction, but the underlying states that give rise to these lesions of function have not been made clear, nor has this been generally seriously attempted in the works treating of nervous disorders. We can say therefore with Landon Carter Gray, in Dercum's text-book of nervous diseases, that the intimate pathology of tremor has been so far an unknown quantity, notwithstanding all the clinical studies and pathologic investigations of the various disorders of
THE PATHOLOGIC MECHANISM OF TREMOR. JAMA. 1898;XXX(1):39–40. doi:10.1001/jama.1898.02440530045006
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