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There are few practitioners throughout the length and breadth of the land who do not, in the course of a year, meet with more or less classic instances of interstitial nephritis, commonly styled Bright's disease.
Although this renal lesion is encountered among rural dwellers, it is far more likely to proclaim its presence among those who by their devotion to urban life outrage Nature, and sooner or later pay the bill in chronic constipation, catarrhs, auto-intoxication in its myriad forms, in short all those disordered conditions that predispose to the final production of what Schmeichler has aptly characterized as " connective tissue individuals," persons whose viscera and other highly specialized organs become the seat of interstitial processes. Thus is the foundation for interstitial nephritis laid, and though in its earliest phases the disease may be many sided, presenting a variation in subjective and objective symptoms often baffling to the practitioner, when
THE PROGNOSTIC IMPORTANCE OF THE APPEARANCE OF EYE LESIONS IN INTERSTITIAL NEPHRITIS. JAMA. 1898;XXX(1):41–42. doi:10.1001/jama.1898.02440530047008
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