In 1895 Denys and Leclef immunized rabbits by injecting them with small but gradually increased doses of a virulent streptococcus, and succeeded in getting animals that were resistant to about one thousand times the minimum fatal dose for their organism. At about the same time, Marmorek, Roger and also Denys and Leclef immunized horses and mules against these organisms, and each of them obtained an antiserum that had some protective properties against the particular strain of streptococcus used in preparing the serum. Since that time many other experimenters have prepared antistreptococcus sera which protected laboratory animals against many times the minimum fatal dose of the streptococcus used in preparing the serum, but it is still an open question whether or not any of these sera protects against a streptococcus coming from a different source and rendered virulent for an animal of a different species. Some investigators, as Van de Velde,
THE MODE OF ACTION OF ANTISTREPTOCOCCUS SERUM.. JAMA. 1904;XLIII(26):1975–1976. doi:10.1001/jama.1904.02500260065006
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