Involuntary discharge of the contents of the urinary bladder is physiologic in infants, ceasing at varying times in different individuals. Control of the sphincter of the bladder by day is acquired earlier than such control by night. Intercurrent disease may delay the manifestation of continence. When the lack of control persists beyond the third year it may be considered abnormal, and it is then designated enuresis. In the absence of disease of the nervous system the disorder has been thought, on the one hand, to be merely a functional disturbance, or, on the other hand, to be a symptom or a sequel of underlying or antecedent disease. The distinction between functional and organic disease is, however, only one of degree, and while tangible evidence demonstrative of a pathologic basis is not obtainable in every instance of enuresis, it must be inferred that some morbid process or abnormal condition is present,
ENURESIS IN CHILDHOOD.. JAMA. 1904;XLIII(26):1976–1977. doi:10.1001/jama.1904.02500260066007
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