Some doubt yet exists as to the value of cryoscopy from the diagnostic and prognostic points of view, and as to the validity of conclusions to be drawn from studies of the molecular concentration of the blood, as determined from the freezing point of the urine, and it is to be feared that the hopes aroused by the earlier investigations on this subject will not be realized. The freezing point may be reduced, among other causes, by disorders that cause interference with the circulation, such as uncompensated cardiac lesions and disease of the blood-vessels and the liver; also as a result of the presence of large tumors, especially in the abdomen, interfering with the circulation and giving rise to symptoms of stasis and exerting pressure on the ureters. It has been thought that if in the presence of disease of the uropoietic system the molecular concentration of the blood is
THE INFLUENCE OF DISEASE OF ONE KIDNEY ON THE MOLECULAR CONCENTRATION OF THE BLOOD. JAMA. 1904;XLIII(26):1978. doi:10.1001/jama.1904.02500260068012
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