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August 2, 1890


JAMA. 1890;XV(5):181-182. doi:10.1001/jama.1890.02410310021002

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Addison's Disease, with Cancer and Tuberculosis of the Suprarenal Capsules.  Fleiner (Berl. Klin. Wochenschr.; Schmidt's Jahrbucher) gives the history of a man 44 years of age, with tuberculous heredity, who presented, after exposure to cold in October, 1888, brownish-yellow spots on the back and breast. From the middle of April, 1889, increased weakness, dyspepsia, and impotence, with general darkening of the skin. Upon his reception in the hospital, the skin was of a brown color throughout, the nipples dark brown, and the axillæ and genitals nearly black. In the mucous membrane of the mouth brown spots were to be seen. In the umbilical region was an uneven, hard, immovable tumor, painful on pressure. From the nature of the symptoms, the muscle weakness, dyspepsia, pigmentation, wasting, and the situation of the tumor, in the retro-peritoneal lymphatic glands, a diagnosis of morbus Addisonii was made, the tumor probably involving the suprarenal

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