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Our attention was first called to the use of orexin by the paper of Professor F. Penzoldt in the Therapeutische Monatshefte, for February, 1890. The term was applied to the hydrochlorate of phenyldihyrochinazolin (C14H12N2Hcl) on account of its supposed properties as an appetizer and digestive. It is a whitish powder, having a bitter, burning taste; and, used experimentally on animals, was toxic only in large doses, and had no escharotic action on the mucous membrane of the conjunctiva, stomach, or subcutaneous cellular tissue. In man, a dose of 7½ grains produced a good appetite; and it was ascertained, by examinations with the stomach tube of test meals during their digestion, that 3¾ grains of the drug reduced the digestive period of wheat bread half an hour, and of beef-steak by thirty to thirty-eight minutes. With 7½ grains, the digestive period of bread was reduced by three-quarters of an hour, and
THE FAILURE OF OREXIN AS A STOMACHIC. JAMA. 1890;XV(8):289. doi:10.1001/jama.1890.02410340021003
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