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January 21, 1905


JAMA. 1905;XLIV(3):198-204. doi:10.1001/jama.1905.92500300030001i

INTRODUCTION.  Although a great deal of work has been done on the mechanism of streptococcus infection, both with normal and with immunized animals, many points are still left entirely in the dark. In the experiments described in this paper, an attempt is made to throw additional light on some of these points, but on account of the many inherent difficulties, the results which I have achieved by no means exhaust the problem.Shortly after the publication of his classical paper on phagocytosis in daphnia, Metchnikoff1 made a study of phagocytosis of streptococci in the human body, in cases of erysipelas. He concluded from his observations that streptococci gain entrance through abrasions of the skin, multiply and set up an inflammation.

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