When Cohnheim demonstrated that inflammation and suppuration are due to an emigration of the white corpuscles, a great advance was made in pathology. Since then the importance of the white blood corpuscles has been increasing with each year.
If leucocytes consisted of but a single variety of cells, with common functions, the study of leucocytosis would be reduced to a simple process. It would then be sufficient simply to ascertain the degree of leucocytosis by estimating the total number of leucocytes to a cubic millimeter of blood.It is well known, however, that the white blood corpuscles consist of several more or less distinct varieties. Many attempts have been made to differentiate these types, resulting in not a little confusion in the nomenclature thus introduced.1. A classification has been based on the nature of the behavior of the cells to microchemic reagents, giving us acidophile, basophile and
HOLMES AM. THE NATURE AND SIGNIFICANCE OF LEUCOCYTOSIS.. JAMA. 1905;XLIV(4):257–263. doi:10.1001/jama.1905.92500310001001