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Article
September 27, 1890

EXPERIMENTAL RESEARCHES ON THE PATHOLOGY OF FEVER.

JAMA. 1890;XV(13):472-473. doi:10.1001/jama.1890.02410390024005

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Abstract

Roussy (Arch. de Physiol., xxii, p. 354, 1890) has recently added some original experiments to our knowledge of the febrile process. He has observed several cases of high temperature of brief duration from the use of stale beer, decayed flesh, and drinking stagnant water containing vegetable matter, such as hay, leaves, etc. He refers the cause of this fever to soluble chemical substances rather than to a specific microörganism. In experiments upon animals he found that intravenous injections of water containing decaying organic matter produced an intense fever after reaching 42° C., and marked gastro-intestinal disturbance, when a like quantity of the same substance introduced into the stomach did not cause fever or other disorders.

The writer especially calls attention to the high fever produced by beer yeast. When rubbed up with distilled water, and after 24 hours filtered, and a cubic centimetre of filtrate injected, hypodermatically, it is followed

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