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October 18, 1890


JAMA. 1890;XV(16):580-581. doi:10.1001/jama.1890.02410420024005

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A few weeks ago we referred editorially to some experimental work of Roussy upon the pathology of fever, in which he demonstrated what appears to be a fever producing albuminoid, which he termed "pyretogenin;" we have now to mention the labors of Brieger and Fränkel (Berl. Klin. Wochenschr.—Centralblatt für Physiologie) upon the toxic substance produced by the diphtheria bacillus of Löffler.

Pure cultures of the bacillus were prepared in large quantity in pepton-broth with or without the addition of glycerine. Roux and Versin had previously separated the toxic substance from bouillon cultures and believed that it belonged to the class of enzyms, a conclusion which the writers cannot indorse. They succeeded in obtaining the substance dry and class it among the albuminoid bodies, the "toxalbumen" as they name them.

The cultures were at first passed through a Chambelain clay filter. The germ free, lemon yellow, clear filtrate proved to be

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