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February 4, 1905

Special Article.IMMUNITY.

JAMA. 1905;XLIV(5):389-391. doi:10.1001/jama.1905.02500320053002


INFECTIOUS ETIOLOGY.  The microbic cause of a disease must be in hand before any logical attempt can be made to prepare an immune serum for the disease. It is not in all cases necessary that the organism be cultivated artificially, however; the conditions in rinderpest may be cited in which the body fluids of a diseased animal, known to contain the infectious agent, are used for immunization, although the microbe itself can not as yet be cultivated or recognized.There are so many possibilities of error, and so many errors have actually been made in regard to infectious etiology, that certain requirements in the way of proof are now habitually demanded before an organism can be accepted as the cause of a disease. These requirements are most frequently expressed in the form of Koch's laws, which may be stated as follows: 1. The suspected organism must be cultivated