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Article
February 4, 1905

TRUTH AND POETRY CONCERNING URIC ACID. IV.

JAMA. 1905;XLIV(5):394-395. doi:10.1001/jama.1905.02500320058006
Abstract

Horbaczewski, as we have pointed out, demonstrated the very important fact that uric acid may be derived from nucleins, but went off at a tangent and maintained that it does not come from all nucleins, but only from the nucleins of leucocytes. His arguments, it must be admitted, sounded plausible enough. He maintained that his studies showed, as a rule, a parallelism between leucocyte counts and uric-acid excretion. Where the parallelism failed he explained the discrepancy by assuming a class of leucocytoses without leucocytic destruction. The blood of children contains more leucocytes than that of adults and this, he believed, accounts for the relatively great excretion of uric acid in the former. Further, he brought the increased excretion of uric acid after eating, especially after a meat diet, into relation with the digestive leucocytosis. Feeding nucleins increased uric-acid excretion, but so convinced was he of his new view, that he

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