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That this disease is to be classified among the acute infectious disorders, dependent upon a specific infectious microörganism, is now generally believed. Whether the disease is at first a local trouble, with secondary infection of the organism, or whether it is a constitutional affection from the beginning, with local manifestations, are questions upon which the profession is still divided. Certain it is that abundant clinical experience has taught the value of antiseptic applications to the affected part. This rule has been evolved in the face of constant reiteration of the constitutional nature of the affection and the consequent valuelessness of such local treatment. We may remark in this connection that recent experimental work upon the Klebs—Löffler bacillus has shown that it is capable of producing an exceedingly poisonous albuminoid, when grown in nutrient media. This experimental fact lends additional weight to the clinical value of local antiseptic measures in this
TREATMENT OF DIPHTHERIA. JAMA. 1890;XV(21):760–761. doi:https://doi.org/10.1001/jama.1890.02410470024004
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