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February 18, 1905


JAMA. 1905;XLIV(7):550-552. doi:10.1001/jama.1905.02500340038007


Slowly but surely, as we have seen, the truth concerning the formation of uric acid in the body was being found out. An origin from the metabolism of the nuclein of the body cells had been established; the possibility of the formation of uric acid directly from the nucleins or xanthin bases of the foods had been definitely demonstrated; and, as was hinted in the concluding paragraph of our last article, the possibility of a third mode of formation, namely, through synthesis of simpler chemical compounds, began to be considered.

Efforts to solve the problem as to whether or not synthetic formation of uric acid occurs in the body were made in various ways. Some tried to increase uric-acid excretion by feeding substances from which uric acid can be manufactured synthetically outside the body; others by feeding substances which are known to be derived from the decomposition of uric

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