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For some time I have felt the need of an antiseptic remedy which would be efficient, and non-irritating to the eye. While formalin is one of our best, if not the best of antiseptics, a solution of even 1 to 5,000 causes considerable pain. The action of sublimate is very superficial, and clinically unsatisfactory. Boric acid and iodoform are only very slightly antiseptic. I have also desired to get some of the properties of iodin, the tincture of which is well known to be curative when applied to ulcus corneæ; on account of its irritative effects its usefulness is very limited.
I have recently used antinosin in a considerable number of cases (both in my private and clinical practice) of catarrhal, palpebral and follicular conjunctivitis, phlyctenulæ, ulcus corneæ, blepharitis marginalis, and also in otitis media purulenta. In a 1 to 2 per cent, solution it does not cause pain in
COLEMAN WF. ANTINOSIN IN THE TREATMENT OF DISEASES OF THE EYE AND EAR. JAMA. 1898;XXX(5):256–257. doi:10.1001/jama.1898.72440570024001o
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