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December 13, 1890


JAMA. 1890;XV(24):859-862. doi:10.1001/jama.1890.02410500015003

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Immunity and Infection.  —These conditions have recently attracted marked attention from Continental writers, especially in Italy and France. Numerous theories have been advanced, none of them can be said to have been wholly satisfactory, or to account for all the varying and apparently contradictory facts.Charrin et Roger (Contribution à l'étude expérimentale du surmenage. Son influence, surl'infection. Arch. de Physol.) have made some experiments regarding the effect of fatigue upon infection, upon lines laid down by Solowieff, who demonstrated upon horses and men that great fatigue favored the development of certain infectious disorders. In their experiments animals were employed, that had been exercised in a revolving drum. The reaction of different species to this treatment was found to vary greatly, rabbits and guinea-pigs soon presented evidences of pain, fright and vertigo, that were soon followed by a fall of temperature and death. Dogs, cats and white rats bore this extreme

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