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December 20, 1890


JAMA. 1890;XV(25):903. doi:10.1001/jama.1890.02410510023006

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While it is perhaps idle, we cannot refrain from speculating a little as to the nature of the substance used by Koch. When his paper was read before the Congress it was supposed that it was in the nature of a minimized virus, a kind of inoculation like that of Pasteur. This idea came from confounding the researches of Goucher and Martin who published their papers shortly after his. A careful reading of Koch's communication would at once dispel this, as he speaks of it as a remedy or substance, in much the same terms as one would speak of a drug. Since the second paper, some salt of gold has been thought to be the curative agent. We doubt, however, if it belongs to any of these classes, as no knowu chemical substance or drug will produce the stormy febrile movement, with the exception of those that are formed

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