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February 5, 1898


Author Affiliations


JAMA. 1898;XXX(6):294-299. doi:10.1001/jama.1898.72440580010001b

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From the very beginning of the application of antitoxins in diphtheria, tetanus and other infections, it was hoped that it would also be beneficial in tuberculosis, and to that end many investigators have labored faithfully in all parts of the world. Maragliano, in Italy, first sought a remedy in the natural blood serum of the ass, and in the latter part of 1885 or in 1886, he reported the results of his work with the serum of the same animal, previously treated to increase immunization. Prior to this, however, Richet, Héricourt and others in Europe had used the natural dog blood serum in various forms of the disease. I began to immunize horses against this affection in 1894, and in January, 1895, reported the first clinical results with the first immunized horse blood serum ever obtained or used, so far as I am able to learn. Many criticisms, kind and

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