Coincidently with the study of the methods by which uric acid is formed and destroyed in the body, efforts were made to determine the exact localization of these processes. The site of formation of uric acid was one of the earliest points to be studied, and the problem was approached in various ways. At first, certain organs supposedly related to uric-acid formation were removed and the metabolic changes following the operation studied. Thus an idea had early gained ground that uric acid is formed in the kidneys. Zalesky,1 who was unable to demonstrate the presence of uric acid in the normal blood of birds and snakes, declared that on tying the ureters deposits of uric acid appear first in the kidneys, then in the adjacent lymphatic system and, later, in the blood and in the other tissues. In other words, the deposits gradually spread from the kidneys as
TRUTH AND POETRY CONCERNING URIC ACID.. JAMA. 1905;XLIV(9):716–717. doi:10.1001/jama.1905.02500360048008
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