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Article
March 4, 1905

THE TOXIC EFFECTS OF FORMALDEHYD.

JAMA. 1905;XLIV(9):717. doi:10.1001/jama.1905.02500360049009
Abstract

In another editorial we call attention to the increasing use of formaldehyd, and to the effects which it produces locally on the skin of the hands. Inasmuch as its use has been suggested as an inhalant in respiratory diseases, the recent work of Fischer1 on the toxic effects of the various formaldehyd preparations is of interest. In this work, which was experimental, the drug was introduced by various routes into the bodies of animals. In some instances animals were subjected to the fumes in rooms which had been fumigated in the ordinary way, in other instances the drug was introduced into the stomach, peritoneal cavity or subcutaneous tissues. The general effect was the same whatever route was used. Not only were local lesions of an inflammatory character produced in all instances, but there was evidence that the drug was absorbed and produced important lesions of the parenchymatous organs, especially

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