Serum therapy has been so extensively used that scarcely a well informed person can be found who does not entertain an opinion either for or against it.
However, the principles underlying this method of medication, the nature of toxins and antitoxins, their mode of preparation, administration and action are very imperfectly understood.
A great variety of opinions are held both by the profession and the laity concerning the effects of this treatment in tuberculosis. Many of these opinions however are based upon no firmer foundation than that of prejudice.
For some time past I have used with my tuberculous patients, a serum prepared by immunizing the horse with Koch's old tuberculin. I have obtained from this product very satisfactory results in several cases.
Soon after the introduction of Koch's new "tuberculin T. R.," I tested its utility on a few well selected cases of tuberculosis. A short time later I
HOLMES AM. A CLINICAL STUDY OF TUBERCULOUS CASES TREATED WITH THE NEW ANTIPHTHISIC SERUM T. R. (FORMULA OF FISCH.). JAMA. 1898;XXX(6):303–308. doi:10.1001/jama.1898.72440580019001d
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